Contact：tangfuchou@cpl.ac.cn
Education
2003, Ph. D., Peking University, Biology
1998, B. S., Peking University, Biology
Academic Experience
2015-Present, Peking Unviersity-Tsinghua University Center for Life Sciences, Principle Investigator
2010-Present, BIOPIC, College of Life Sciences, Peking University, Principle Investigator
2004-2010, Gurdon Institute, University of Cambridge, Postdoctoral Research Associate
Overview of Academic Research
Stem cells have self-renewal ability and multi-lineage differentiation potential, hence and are crucial for mammalian embryonic development and adult life. Dissecting the molecular mechanisms of stem cell regulation is important for understanding mammalian growth and development, and for its application of regeneration medicine for in order to cure human diseases. Our lab focuses on the epigenetic mechanisms of human germline cell development as well as human early embryos. Through this, we want to understand the epigenetic regulation of human early embryonic development and the global epigenetic reprogramming such as during the development of human germline cells. We use single cell genome, transcriptome, DNA methylome, as well as multi-omics sequencing technologies to analyze the epigenetic regulation of the dynamic gene expression network in human early embryos at single-cell and single-base resolution.
Major Honor and Awards
2021, The Xplorer Prize
2017, Bayer Investigator Award
2015, Guxiaocheng Lecture Award, Ray Wu Fouddation
2015, "Accurate Deduction of Maternal Genome Information" Listed as Top 10 China’s Scientific Advances in 2014
Representative Research Achievements
1. Zhou Y, Bian S, Zhou X, Cui Y, Wang W, Wen L, Guo L, Fu Wei*, Tang Fuchou*. Single-Cell Multiomics Sequencing Reveals Prevalent Genomic Alterations in Tumor Stromal Cells of Human Colorectal Cancer. Cancer Cell. 38(6):818-828.e5(2020) (*: Co-corresponding authors).
2. Zhou F, Wang R, Yuan P, Ren Y, Mao Y, Li R, Lian Y, Li J, Wen L, Yan L, Qiao J*, Tang Fuchou*. Reconstituting the transcriptome and DNA methylome landscapes of human implantation. Nature. 572: 660-664 (2019) (*: Co-corresponding authors).
3. Zhu P, Guo H, Ren Y, Hou Y, Dong J, Li R, Lian Y, Fan X, Hu B, Gao Y, Wang X, Wei Y, Liu P, Yan J, Ren X, Yuan P, Yuan Y, Yan Z, Wen L, Yan L*, Qiao J*, Tang Fuchou*. Single-cell DNA methylome sequencing of human preimplantation embryos. Nature Genetics. 50: 12-19 (2018) (*: Co-corresponding authors).
4. Zhong S, Zhang S, Fan X, Wu Q, Yan L, Dong J, Pan N, Xu X, Tang Fuchou*, Zhang J*, Qiao J*, Wang X*. (2018). A single-cell RNA-seq survey of the developmental landscape of the human prefrontal cortex. Nature. 555: 524-528
5. Bian S, Hou Y, Zhou X, Li X, Yong J, Wang Y, Wang W, Yan J, Hu B, Guo H, Wang J, Gao S, Mao Y, Dong J, Zhu P, Xiu D, Yan L, Wen L, Qiao J*, Tang Fuchou*, Fu W*. Single-cell multiomics sequencing and analyses of human colorectal cancer. Science. 362: 1060-1063 (2018) (*: Co-corresponding authors).
6. Li L, Dong J, Yan L, Yong J, Liu X, Hu Y, Fan X, Wu X, Guo H, Wang X, Zhu X, Li R, Yan J, Wei Y, Zhao Y, Wang W, Ren Y, Yuan P, Yan Z, Hu B, Guo F, Wen L, Tang Fuchou*, Qiao J*. Single-cell RNA-seq analysis maps development of human germline cells and gonadal niche interactions. Cell Stem Cell. 20: 858-873 (2017) (*: Co-corresponding authors).
7. Guo F, Yan L, Guo H, Li L, Hu B, Zhao Y, Yong J, Hu Y, Wang X, Wei Y, Wang W, Li R, Yan J, Zhi X, Zhang Y, Jin H, Zhang W, Hou Y, Zhu P, Li J, Zhang L, Liu S, Ren Y, Zhu X, Wen L, Gao Y, Tang Fuchou*, Qiao J*. The Transcriptome and DNA Methylome Landscapes of Human Primordial Germ Cells. Cell. 161: 1437-1452 (2015) (*: Co-corresponding authors).
8. Guo H, Zhu P, Yan L, Li R, Hu B, Lian Y, Yan J, Ren X, Lin S, Li J, Jin X, Shi X, Liu P, Wang X, Wang W, Wei Y, Li X, Guo F, Wu X, Fan X, Yong J, Wen L, Xie SX, Tang Fuchou*, Qiao J*. The DNA methylation landscape of human early embryos. Nature. 511: 606-610 (2014) (*: Co-corresponding authors).
9. Yan L, Yang M, Guo H, Yang L, Wu J, Li R, Liu P, Lian Y, Zheng X, Yan J, Huang J, Li M, Wu X, Wen L, Lao K, Li R*, Qiao J*, Tang Fuchou*. Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells. Nature Structural & Molecular Biology. 20: 1131-1139 (2013) (*: Co-corresponding authors).